Afis Life Commodity Supply

Daun Sirsak (Soursop Leafs) (Anonna Muricata)

Studies
Many studies reported on this plant.
• Cytotoxicity / Antileishmanial: Cytotoxicity and antileishmanial activity of Annona muricata pericarp: Extracts and fractionation led to the isolation of three acetogenins—annonacin, annonacin A and annomuricin A
• Diabetes: (1) Morphological Changes and Hypoglycemic Effects of Annona Muricata Linn. (Annonaceae) Leaf Aqueous Extract on Pancreatic Cells of Streptozotocin-Treated Diabetic Rats. (2) Histopathologic study showed regeneration of ß-cells of pancreatic islets in A. muriatica- treated rats compared to untreated diabetic group.
• Anti-Herpes Simplex Virus: Study showed the extract of AM to inhibit the cytopathic effect of HSV-1 on vero cells indicasting an anti-HSV1 potential.
• Anticancer / Acetoginins: (1) There are much publicized studies on the anti-tumor, anti-cancer and selective toxicity of Annona muricata against several types of cancer cells. One study showed that one of the acetoginins was seletively cytotoxic to colon adenocarcinoma cells, with a potency 10,000 times that of adriamycin.

• Anti-Hyperlipidemia: Study of methanolic extracts of AM on serum lipid profiles in experimentally-induced diabetic Wistar rats showed antihyperlipidemic activities with significant reductions in total cholesterol, LDL and VLDL and a significant increase in HDL and antiatherogenic index